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KMID : 1149220100180010155
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Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 1 p.155 ~ p.167
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Effects of Forsythiae Fructus on CRF, c-Fos and TH in the Forced Swimming Test
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Kim Hyo-Joon
Lee Tae-Hee
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Abstract
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Objectives: In order to investigate the antidepressant effects of Forsythiae Fructus(FF), we performed the Forced Swimming Test(FST). Also the expressions of corticotropin-releasing factor (CRF), c-Fos and tyrosine hydroxylase(TH) were measured by immunohistochemical method at paraventricular nucleus(PVN), ventral tegmental area(VTA) and locus coeruleus(LC).
Methods:Spraque-Dawley rats were administered FF extract(100 mg/kg, 400 mg/kg) intragastrically three times prior to the FST.
Results:The duration of immobility in the FST was significantly decreased in the FF 100 mg/kg, 400 mg/kg groups(p<0.05). The expression of CRF was significantly reduced in the FF 100 mg/kg and 400 mg/kg groups(p<0.001). c-Fos expression was significantly decreased at PVN in the FF 100 mg/kg group(p=0.069). TH expression at VTA was significantly increased in the FF 100 mg/kg and 400 mg/kg groups(p<0.05). TH expression at LC was not significantly changed(p=0.346).
Conclusions:According to the results, it can be suggested that Forsythiae Fructus has antidepressant effect via the decreased immobility through the reduction of CRF and c-Fos expression at PVN.
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KEYWORD
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Forsythiae Fructus, FST, CRF, c-Fos, TH, anti-depression
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